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figure {
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input[type='radio'] {
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textarea {
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table {
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div#besetsel-form h3 {
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div.besetsel-body {
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div#besetsel-form div {
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div#besetsel-form a {
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body.scanned-article-browse.article .pmc-grid {
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body.scanned-article-browse.article .eight_col {
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body.scanned-article-browse.article .four_col {
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body.table .grid .col {
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noscript p.nojs {
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}
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}
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.large-number-list {
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div.messagearea {
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div.browsername {
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}
#footer a {
	color: rgb(20, 55, 108); text-decoration: none;
}
#NCBIFooter_dynamic a:hover {
	text-decoration: underline;
}
#footer a:hover {
	text-decoration: underline;
}
.contact_info a:hover {
	text-decoration: underline;
}
#footer-contents-right {
	text-align: right; float: right;
}
#footer-contents-right a {
	height: 41px; text-indent: 10em; overflow: hidden; padding-top: 14px; float: left;
}
#footer-contents-right div {
	display: inline;
}
#nlm_thumb_logo a {
	background: url("/coreweb/images/ncbi/footer/footer_imgs.png") no-repeat 0px 100%; width: 34px; margin-right: 14px;
}
#nih_thumb_logo a {
	background: url("/coreweb/images/ncbi/footer/footer_imgs.png") no-repeat -35px 100%; width: 40px; margin-right: 14px;
}
#hhs_thumb_logo a {
	background: url("/coreweb/images/ncbi/footer/footer_imgs.png") no-repeat -75px 100%; width: 39px; margin-right: 14px;
}
#usagov_thumb_logo a {
	background: url("/coreweb/images/ncbi/footer/footer_imgs.png") no-repeat -114px 100%; width: 89px;
}
#footer-contents-left p.address {
	margin: 0px; line-height: 18px;
}
#footer-contents-left a {
	font-weight: bold;
}
#footer-contents-left span.url a {
	font-weight: normal;
}
#footer-contents-left p.address .adr {
	display: block;
}
#footer {
	background: url("//static.pubmed.gov/portal/portal3rc.fcgi/3999366/img/3418709") repeat-x left top rgb(229, 229, 229); clear: both; z-index: 1; zoom: 1;
}
#footer {
	text-align: center; color: rgb(20, 55, 108); overflow: visible; background-color: rgb(255, 255, 255);
}
.contact_info {
	text-align: center; color: rgb(20, 55, 108); overflow: visible; background-color: rgb(255, 255, 255);
}
.foot_list {
	margin: 4.5em 0px 0px; padding: 0px; width: 20%; text-align: left; float: left;
}
.foot_list li {
	list-style-type: none;
}
.foot_list li h3 {
	margin: 0px 0px 0.05em; text-transform: uppercase;
}
.offscreen_noflow {
	margin: 0px; padding: 0px; height: 0px; text-indent: -9999em; float: left; _display: block;
}
.contact_info {
	margin: 1em 1.6em; text-align: left; clear: both;
}
.subfooter {
	overflow: hidden; margin-left: 1.6em;
}
#footer #external-disclaimer {
	padding: 0.68em; line-height: 1em;
}
#footer #external-disclaimer a {
	text-decoration: underline;
}
.header {
	background: url("//static.pubmed.gov/portal/portal3rc.fcgi/3999366/img/2375536") repeat-x left bottom rgb(213, 213, 213); margin-bottom: 1.23em; position: relative; z-index: 20;
}
.header a {
	text-decoration: none;
}
.header a:hover {
	text-decoration: underline;
}
.search {
	margin: 0px 0px 0px 13.53em; padding: 1.2em 0px 0.7em;
}
.search_form {
	
}
.search_form select {
	font-family: arial,helvetica,sans-serif; margin-right: 0.2em;
}
.search_form .jig-ncbiclearbutton-wrap {
	font-family: arial,helvetica,sans-serif; margin-right: 0.2em;
}
.search_form button {
	font-family: arial,helvetica,sans-serif; margin-right: 0.2em;
}
.search_form select {
	width: 8.5em; bottom: 1px; font-size: 1.07em; margin-right: 0.3em; position: relative;
}
.search_form select optgroup {
	color: rgb(85, 85, 85); padding-left: 0.2em; font-style: normal;
}
.search_form select optgroup option {
	color: rgb(0, 0, 0);
}
.search_form input {
	width: 48%; font-size: 1.15em; display: inline-block; _width: 100%;
}
.search_form div.nowrap {
	
}
.search_form button.nowrap {
	
}
.search_form div.nowrap div.nowrap {
	
}
.search_form .nowrap {
	display: inline;
}
.searchlinks {
	margin: 0.2em 0px 0px 9.6em; _zoom: 1;
}
.searchlinks li {
	margin-right: 1.2em; zoom: 1;
}
.searchlinks .help {
	right: 1em; margin-right: 0px; position: absolute; _margin-top: -.1em;
}
.searchlinks .hidden {
	display: none;
}
.searchlinks .visible {
	display: inline;
}
.search_form .wrap {
	display: inline; position: relative; _width: 70%;
}
#cl {
	top: -12px; right: 8px; position: absolute;
}
.search_form button {
	margin: 0px 0.2em; padding: 0.2em 0.4em; border-radius: 5px; border: 0px currentColor; width: auto; overflow: visible; cursor: pointer; box-shadow: 0.1em 0.1em 0.1em rgba(0,0,0,0.5); background-color: rgb(221, 221, 221); -moz-border-radius: 5px; -webkit-border-radius: 5px; text-shadow: .1em .1em .1em rgba(0, 0, 0, .5); -webkit-box-shadow: .1em .1em .1em rgba(0, 0, 0, .5); -moz-box-shadow: .1em .1em .1em rgba(0, 0, 0, .5); _padding: .2em .4em;
}
.search_form button.button_search {
	color: rgb(255, 255, 255); font-size: inherit; font-weight: bold; background-color: rgb(68, 119, 170);
}
.search_form button.button_search:active {
	background-color: rgb(76, 150, 223);
}
.search_form button.button_preview {
	color: rgb(255, 255, 255); font-weight: bold; background-color: rgb(166, 77, 72);
}
.search_form button.button_preview:active {
	background-color: rgb(242, 112, 105);
}
.search_form input:focus {
	-moz-box-shadow: 0 0 .3em rgba(211, 186, 44, .8);
}
.search_form .jig-ncbiclearbutton-wrap {
	border: 1px solid rgb(153, 153, 153); width: 64%;
}
.search_form .jig-ncbiclearbutton-wrap input {
	width: 100%;
}
.search_form .jig-ncbiclearbutton-wrap a.reset {
	top: 50%; margin-top: -7px; margin-left: 0px;
}
.rss_icon {
	top: 3px; margin-right: 0.3em; position: relative;
}
.rss_menu {
	display: none; z-index: 1001;
}
.rss_menu legend {
	margin: 2px 0px 0px 3px; font-weight: bold;
}
.rss_menu ul {
	margin: 0px; padding: 5px 0px 0px; list-style-type: none;
}
.rss_menu ul li {
	margin-bottom: 0.4em;
}
.rss_menu span {
	margin-right: 0.5em;
}
.rss_menu label {
	margin-right: 0.5em;
}
.rss_menu ul input {
	top: 0px;
}
.rss_menu dd {
	margin-bottom: 1em; margin-left: 0px;
}
.rss_menu #rss_name {
	width: 15em;
}
.rss_menu button {
	margin-top: 0.5em;
}
.rss_menu label {
	display: block;
}
.db_logo {
	background: no-repeat left top; width: 100px; height: 36px; text-indent: -9999px; display: block;
}
.res_logo {
	left: 1.23em; width: 11.53em; padding-top: 0.4em; position: absolute;
}
.res_logo h1 {
	margin: 0px; font-weight: normal;
}
.long {
	padding: 0.5em 0px;
}
.long h1 {
	line-height: 1.15;
}
.res_logo h1 a {
	padding: 0.3em 0px; color: rgb(51, 51, 51); display: block; text-shadow: 1px 1px 1px rgba(240, 240, 240, .9);
}
.res_tagline {
	display: none;
}
.res_logo h1 a {
	text-decoration: none;
}
.res_logo h1 a:hover {
	text-decoration: none;
}
.res_logo h1 a:visited {
	text-decoration: none;
}
h1.img_logo {
	margin: 0px;
}
h1.img_logo a {
	padding: 0px;
}
.searchlinks {
	min-height: 1.3em;
}
.browsercheck .warn {
	color: rgb(0, 0, 0);
}
.browsercheck .error {
	color: rgb(0, 0, 0);
}
span.caps {
	text-transform: capitalize;
}
div.success_msg {
	margin: 0.5em; padding: 0.4em; color: black; font-family: helvetica, arial, verdana, sans-serif;
}
div.warn_msg {
	margin: 0.5em; padding: 0.4em; color: black; font-family: helvetica, arial, verdana, sans-serif;
}
div.error_msg {
	margin: 0.5em; padding: 0.4em; color: black; font-family: helvetica, arial, verdana, sans-serif;
}
div.success_msg img {
	top: 0.15em; margin-left: 0.2em; position: relative;
}
div.warn_msg img {
	top: 0.15em; margin-left: 0.2em; position: relative;
}
div.error_msg img {
	top: 0.15em; margin-left: 0.2em; position: relative;
}
div.success_msg {
	border: 1px solid rgb(102, 204, 102); background-color: rgb(204, 255, 204);
}
div.warn_msg {
	border: 1px solid rgb(227, 210, 28); background-color: rgb(255, 255, 239);
}
div.error_msg {
	border: 1px solid rgb(255, 136, 136); background-color: rgb(255, 221, 221);
}
.success {
	margin-right: 0.5em; margin-left: 0.5em;
}
.error {
	margin-right: 0.5em; margin-left: 0.5em;
}
.warn {
	margin-right: 0.5em; margin-left: 0.5em;
}
.info {
	margin-right: 0.5em; margin-left: 0.5em;
}
.suggest {
	margin-right: 0.5em; margin-left: 0.5em;
}
.hi_warn {
	margin-right: 0.5em; margin-left: 0.5em;
}
.navlink-box > .page-breadcrumbs li a {
	background: url("//static.pubmed.gov/portal/portal3rc.fcgi/3999366/img/3848514") no-repeat right; padding-right: 8px;
}
.format-menu {
	margin-bottom: 1em;
}
.format-menu ul {
	margin: 0px; padding: 0px; display: inline;
}
.format-menu h2 {
	color: rgb(0, 0, 0);
}
.format-menu ul li {
	margin: 0px 0.3em; display: inline;
}
.format-menu ul li a {
	color: rgb(0, 0, 0);
}
.format-menu ul li.selected {
	color: rgb(94, 94, 94);
}
div.try-button {
	text-align: center; margin-top: 0.3em;
}
.portlet {
	margin: 0.76em 0px 2.15em; line-height: 1.23em; overflow: visible; padding-top: 0.46em; border-top-color: rgb(151, 176, 200); border-top-width: 0.4em; border-top-style: solid; zoom: 1;
}
.portlet h1 {
	color: rgb(152, 87, 53); font-weight: bold; display: inline;
}
.portlet h2 {
	color: rgb(152, 87, 53); font-weight: bold; display: inline;
}
.portlet h3 {
	color: rgb(152, 87, 53); font-weight: bold; display: inline;
}
.portlet h4 {
	color: rgb(152, 87, 53); font-weight: bold; display: inline;
}
.portlet h5 {
	color: rgb(152, 87, 53); font-weight: bold; display: inline;
}
.portlet h6 {
	color: rgb(152, 87, 53); font-weight: bold; display: inline;
}
.portlet .whatsthis {
	color: rgb(20, 55, 108); margin-left: 0.3em; white-space: nowrap;
}
.portlet ul {
	margin: 0px; padding: 0px;
}
.portlet ul li {
	overflow: visible; padding-bottom: 1px; margin-top: 0.46em; border-bottom-color: rgb(204, 204, 204); border-bottom-width: 1px; border-bottom-style: dotted; list-style-type: none; position: relative; zoom: 1;
}
.portlet .portlet_list li {
	border-bottom-color: currentColor; border-bottom-width: 0px; border-bottom-style: none;
}
.portlet ul li a {
	color: rgb(20, 55, 108); font-weight: normal; text-decoration: none;
}
.portlet ul li a:hover {
	border-bottom-color: currentColor; border-bottom-width: 0px; border-bottom-style: none;
}
.portlet ul li a:active {
	border-bottom-color: currentColor; border-bottom-width: 0px; border-bottom-style: none;
}
.portlet ul a {
	_display: block; _float: left; _clear: left;
}
.portlet .seemore {
	text-align: right; color: rgb(20, 55, 108); font-size: 0.92em; text-decoration: none; margin-top: 0.8em; display: block;
}
.portlet .portlet_section_header {
	color: rgb(0, 0, 0); font-weight: bold; text-decoration: none; border-bottom-color: currentColor; border-bottom-width: 0px; border-bottom-style: none;
}
.portlet li.two_line {
	height: 2.36em; overflow: hidden;
}
.portlet .two_line a {
	overflow: hidden; display: block; max-height: 2.45em;
}
.portlet .long_info {
	color: rgb(119, 119, 119);
}
.portlet p {
	color: rgb(119, 119, 119);
}
.portlet .two_line .source {
	color: rgb(119, 119, 119);
}
.portlet .one_line_source {
	color: rgb(119, 119, 119);
}
.portlet_content .image .desc {
	color: rgb(119, 119, 119);
}
.portlet ul li .desc a {
	color: rgb(119, 119, 119);
}
.portlet .two_line .source {
	right: 0px; padding-left: 0.3em; white-space: nowrap; position: absolute; background-color: white;
}
.portlet .one_line_source {
	right: 0px; padding-left: 0.3em; white-space: nowrap; position: absolute; background-color: white;
}
.portlet .two_line .source {
	top: 1.23em;
}
.portlet .two_line .tertiary {
	padding: 0.1em 0px 0px 0.3em; top: 1.5em; right: 0px; color: rgb(119, 119, 119); font-size: 0.76em; position: absolute; background-color: white;
}
.portlet .portlet_content p {
	margin: 0.8em 0px;
}
.portlet .buttonwrap {
	top: -0.1em; overflow: visible; float: left; position: relative;
}
.portlet .invert {
	padding: 0px 0.2em; color: rgb(255, 255, 255); background-color: rgb(20, 55, 108);
}
.portlet .tertiary {
	top: 0.1em; text-align: right; color: rgb(119, 119, 119); line-height: 1.4em; position: relative;
}
.portlet_content {
	margin: 0px; position: relative;
}
.portlet_content textarea {
	margin: 0px 0px 0.9em;
}
.portlet_content img {
	margin: 0.3em 1.4em 0.7em 0px;
}
.portlet_content .image {
	overflow: hidden; display: block;
}
.portlet_content .image .img_link {
	float: left;
}
.portlet_shutter {
	background: url("//static.pubmed.gov/portal/portal3rc.fcgi/3999366/img/32197") no-repeat left top; top: -0.2em; width: 15px; height: 15px; right: 0px; margin-left: 0.6em; float: right; display: block; position: absolute;
}
.shutter_closed {
	background-position: left bottom;
}
.portlet .related li {
	border-bottom-color: currentColor; border-bottom-width: 0px; border-bottom-style: none;
}
.portlet .right {
	text-align: right;
}
.ra_qry {
	padding-left: 2em;
}
.ra_rcd {
	padding-left: 2em;
}
.ra_qry {
	background: url("//static.pubmed.gov/portal/portal3rc.fcgi/3999366/img/32182") no-repeat 0px 1px;
}
.ra_rcd {
	background: url("//static.pubmed.gov/portal/portal3rc.fcgi/3999366/img/32183") no-repeat 0px 1px;
}
.sensor {
	margin: 1em 0px; padding: 0px 1em 1em; border: 1px solid rgb(200, 221, 235); background-color: rgb(247, 249, 251);
}
.sensor .sensor_head {
	margin-bottom: 0px; position: relative;
}
.sensor .sensor_head h3 {
	font-weight: normal;
}
.sensor h3 {
	margin: 0.69em 0px 0px;
}
.sensor h4 {
	margin: 0.69em 0px 0px;
}
.sensor h5 {
	margin: 0.69em 0px 0px;
}
.sensor h6 {
	margin: 0.69em 0px 0px;
}
.sensor .sensor_content {
	margin-bottom: 1.1em;
}
.sensor p {
	margin: 0px;
}
.sensor .portlet_shutter {
	display: none;
}
.no_p_margins {
	margin: 0px;
}
.portlet_head {
	margin-bottom: 0.46em; position: relative;
}
.portlet_title {
	margin-right: 2em;
}
.sensor_title {
	margin-right: 2em;
}
.portlet_title h3 {
	line-height: inherit;
}
div.port li.item em.error.linklist {
	color: rgb(204, 0, 0); font-size: 1.2em; background-color: rgb(234, 235, 200);
}
div.norender.port {
	font-family: Arial,Lucida Sans,Trebuchet,Sans-Serif;
}
.portlet .ui-ncbitoggler-slave {
	margin: 0px;
}
.portlet .ui-ncbitoggler-slave-open {
	margin: 0px;
}
.blueStyle.portlet {
	background: rgb(255, 251, 238); border-radius: 9px; border: 2px solid rgb(242, 238, 229); margin-top: 1.85em; margin-right: 2px; box-shadow: 1px 1px 2px #ede7da;
}
.blueStyle.portlet > div {
	margin: 1em;
}
.blueStyle.portlet .portlet_head {
	background: rgb(95, 142, 206); margin: -1.65em 0.4em 0em; padding: 0.6em 1em; border-radius: 7px;
}
.blueStyle.portlet .portlet_title h3 {
	color: rgb(255, 255, 255);
}
.blueStyle.portlet .portlet_shutter {
	top: 0.65em; right: 0.8em;
}
.whiteStyle.portlet {
	background: rgb(255, 255, 255); border-radius: 9px; border: 1px solid rgb(242, 238, 229); margin-right: 2px; box-shadow: 1px 1px 2px #ede7da;
}
.whiteStyle.portlet > div {
	margin: 1em;
}
.whiteStyle.portlet .portlet_head {
	background: rgb(255, 255, 255); padding: 0px 1em 0em 0px; margin-top: 0.5em; margin-bottom: 0em;
}
.whiteStyle.portlet .portlet_title h3 {
	color: rgb(0, 51, 102);
}
.whiteStyle.portlet .portlet_shutter {
	top: 0.1em;
}
.inline_sensor {
	border-radius: 9px; border: 1px solid rgb(242, 238, 229); width: 30%; margin-right: 2.8%; margin-bottom: 2em; float: left; box-shadow: 1px 1px 1px #ede7da;
}
.inline_sensor .image {
	border-top-left-radius: 9px; border-top-right-radius: 9px;
}
.right.inline_sensor {
	margin-right: 2px; margin-left: 2.8%; float: right;
}
.inline_sensor h3 {
	background: url("//static.pubmed.gov/portal/portal3rc.fcgi/3999366/img/3593075") repeat-x; margin: 0px; padding: 0.5em; color: rgb(255, 255, 255); font-size: 1.2em; display: block;
}
.inline_sensor .sensor_content {
	margin: 0.5em 0.9em;
}
div#HTDisplay ul li a.hidden {
	display: none;
}
div#HTDisplay div.action {
	width: 100%; overflow: hidden;
}
div#HTDisplay div.action a {
	margin: 0em 0.5em 0.25em; color: rgb(20, 55, 108); font-size: 0.84em; float: right;
}
div#HTDisplay p {
	margin: 1.2em 0em 0.6em 0.5em; color: rgb(20, 55, 108); clear: both;
}
div#HTDisplay p a {
	color: rgb(20, 55, 108);
}
div#HTDisplay p {
	display: none;
}
div#HTDisplay .action a.HTOff {
	display: none;
}
div.HTOff#HTDisplay .action a.HTOn {
	display: none;
}
div.HTOff#HTDisplay p.HTOff {
	display: block;
}
div.HTOn#HTDisplay p.HTOn {
	display: block;
}
div.HTOff#HTDisplay .action a.HTOff {
	display: block;
}
div.HTOn#HTDisplay .action a.HTOn {
	display: block;
}
div#HTDisplay ul.hide {
	display: none;
}
div#HTDisplay p.Err {
	display: block;
}
div.HTOff#HTDisplay a.seemore {
	display: none;
}
div.HTOn#HTDisplay a.seemore {
	display: none;
}
body .popper {
	font-size: 1.2em;
}
div.popper p {
	margin: 0px 0px 0.25em;
}
p#htbpcit {
	font-size: 85%; display: block;
}
p.pmid {
	font-size: 85%; display: block;
}
p#htbpcit {
	font-style: italic;
}
.hidden#htbpopper {
	display: none;
}
div#HTDisplay .ralinkpop {
	width: 350px;
}
div.pmc_para_cit {
	background: white; border-width: 1px 2px 2px; border-style: solid; border-color: black white white; padding: 4px; visibility: hidden;
}
div.stretched.pmc_para_cit {
	border-width: 1px 2px 2px; border-style: solid; border-color: rgb(204, 204, 204); box-shadow: 0.4em 0.4em 0.5em rgba(0,0,0,0.4); -webkit-box-shadow: 0.4em 0.4em 0.5em rgba(0, 0, 0, .4); -moz-box-shadow: 0.4em 0.4em 0.5em rgba(0, 0, 0, .4);
}
div.pmc_para_cit li.expanded span.one_line_source {
	display: none;
}
div.pmc_para_cit li.expanded div.alt-note {
	margin-top: 0.4em; margin-bottom: 0.4em;
}
div.pmc_para_cit div.citation {
	font-size: 0.85em; margin-top: 0.3em;
}
div.pmc_para_cit li.two_line span.one_line_source {
	bottom: 1px;
}
div.pmc_para_cit li.two_line div.alt-note {
	display: none;
}
#body-link-poppers .ui-ncbipopper-wrapper {
	z-index: 2000;
}
#body-link-poppers div.authors {
	font-style: italic; margin-top: 0.5em; margin-bottom: -0.3em;
}
#body-link-poppers div.citation {
	font-style: italic; margin-top: 0.5em; margin-bottom: -0.3em;
}
.ui-ncbipopper-arrow-left {
	padding-top: 1.4em;
}